Job Vacancy: Leading firm seeks Senior Financial Advisor

first_imgJob Vacancy: John F. Loughrey Financial Services has announced a vacancy for a Senior Financial Advisor. John F. Loughrey Financial Services, based in Letterkenny, is the leading firm of impartial financial advisors in the northwest, helping clients for over 30 years.See the full job description and application details below:  Job Vacancy: Leading firm seeks Senior Financial Advisor was last modified: April 2nd, 2019 by Staff WriterShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Financial Advisorfinancial advisorsJob VacancyJohn F LoughreyletterkennySenior Financial Advisorlast_img read more

Researchers use neutrons to make first direct observations of water in lipid

first_imgReviewed by James Ives, M.Psych. (Editor)Sep 21 2018New 3D maps of water distribution during cellular membrane fusion are accelerating scientific understanding of cell development, which could lead to new treatments for diseases associated with cell fusion. Using neutron diffraction at the Department of Energy’s Oak Ridge National Laboratory, researchers have made the first direct observations of water in lipid bilayers used to model cell membrane fusion.The research, published in Journal of Physical Chemistry Letters, could provide new insights into diseases in which normal cell fusion is disrupted, such as Albers-Schönberg disease (osteopetrosis), help facilitate the development of fusion-based cell therapies for degenerative diseases, and lead to treatments that prevent cell-to-cell fusion between cancer cells and non-cancer cells.When two cells combine during fertilization, or a membrane-bound vesicle fuses during viral entry, neuron signaling, placental development and many other physiological functions, the semi-permeable membrane bilayers between the fusing partners must be merged to exchange their internal contents. As the two membranes approach each other, hydration forces increase exponentially, which requires a significant amount of energy for the membranes to overcome. Mapping the distribution of water molecules is key to understanding the fusion process.Related StoriesNANOLIVE‘s novel CX-A defines a new standard for live cell imaging in 96 well plates for continuous organelle monitoring in cell populationsAlternate cell growth pathway could open door to new treatments for metastatic cancersStudy: Megakaryocytes play an important role in cell migrationResearchers used the small-angle neutron scattering (EQ-SANS) instrument at ORNL’s Spallation Neutron Source and the biological small-angle neutron scattering (Bio-SANS) instrument at the High Flux Isotope Reactor, both of which can probe structures as small as a few nanometers in size.”We used neutrons to probe our samples, because water typically can’t be seen by x-rays, and because other imaging techniques can’t accurately capture the extremely rapid and dynamic process of cellular fusion,” said Durgesh K. Rai, co-author and now a post-doctoral associate at the Cornell High Energy Synchrotron Source at Cornell University. “Additionally, the cold, lower-energy neutrons at EQ-SANS and Bio-SANS won’t cause radiation damage or introduce radicals that can interfere with lipid chemistry, as x-rays can do.”The researchers’ water density map indicates the water dissociates from the lipid surfaces in the initial lamellar, or layered, phase. In the intermediate fusion phase, known as hemifusion, the water is significantly reduced and squeezed into pockets around a stalk–a highly curved lipid “bridge” connecting two membranes before fusion fully occurs.”For the neutron scattering experiments, we replaced some of the water’s hydrogen atoms with deuterium atoms, which helped the neutrons observe the water molecules during membrane fusion,” said Shuo Qian, the study’s corresponding author and a neutron scattering scientist at ORNL. “The information we obtained could help in future studies of membrane-acting drugs, membrane-associated proteins, and peptides in a membrane complex.”​Source: https://www.ornl.gov/last_img read more