An enzyme named vinculin undergoes “drastic” conformational changes, reports William A. Weis in the July 29 issue of Nature.1 Vinculin, with over a thousand amino acid links, is important at membrane junctions for transporting materials in and out of the cell. It helps cellular “glue” exit the membrane so that neighboring cells can adhere to one another, such as in epithelial tissues. Weis reports on recent studies that show vinculin undergoes radical conformational changes during its action. It will only build the adhesive junction when the necessary components are in place. Nothing happens unless the participants are ready; “the binding energy of several partners is needed to overcome the thermodynamic and perhaps kinetic barriers to activation,” he says. “Viewed in this way, vinculin functions as a logical AND gate, in which binding of two partners is required to generate an output, in this case a stable multi-protein complex”. What’s more, this automatic regulation is essential for its function; it prevents inappropriate assembly if the amount of product is unstable.1William A. Weis, “Cell biology: How to build a cell junction,” Nature 430, 513 – 515 (29 July 2004); doi:10.1038/430513a.Logic, logic gates, regulation: this is the language of intelligent design. Each of the contacts formed during the “radical” conformational changes of this complicated enzyme is finely tuned to its substrates, and finely tuned to the concentration of ingredients in the cell. And these finely tuned contacts are determined by the specificity of the sequence of amino acids in this protein, each coded in another language—the language of DNA. At every step, this system only makes sense in the context of intelligent design. There is no suggestion in this paper how vinculin’s specificity in adhesive junctions might have evolved. But in the latest ICR Impact article #374 (August 2004), organic chemist Dr. Charles McCombs provides very good reasons why unguided chemistry will never produce such functional complexity and specificity. Unguided chemicals will always follow the laws of (1) chemical stability; i.e., whether the components will react at all, (2) chemical reactivity, or how fast reactants will react, and (3) chemical selectivity, or where the components react. Working through these principles, he shows that amino acids will not join together without help, and even if they did, far more random, useless, nonfunctional polymers with damaging cross-reactions would result. The resulting chain would always form blindly according to the relative binding energies of the amino acids. It takes an organic chemist careful guidance at each step to produce a functional enzyme. “Evolutionists say that nature is blind, has no goal, and no purpose, and yet precise selection at each step is necessary,” McCombs says. Chemicals cannot think, plan or organize themselves, he reminds us, yet Darwinians invoke a false logic that unguided processes yielded logical living systems, like this example with vinculin. The chemist remarks, “Evolutionists just hope you don’t know chemistry!”(Visited 11 times, 1 visits today)FacebookTwitterPinterestSave分享0
How Myia Health’s Partnership with Mercy Virtua… 8 Unusual Ideas for a Dentistry Business Tags:#body scale#BPM#fitness#Go#health#Health Mate#Internet of Things#IoT#Nokia#smartwatch#Steel HR#wearables#Withings FDA Extends Collaboration on Living Heart Proje… Nokia has rebranded all Withings products and will be retiring the brand, a year after acquiring the French health-tech company for $191 million.The three wearables, Go, Steel, and Steel HR, will remain part of Nokia’s portfolio. Go is a simple E-Ink activity and sleep tracker with one year charge, available for $50. Steel does all that with a more stylish design and connects to the Health Mate app, it costs $130. Steel HR adds heart-rate monitoring and text, call, and notification alerts and drops to 25 days of charge for $180.See Also: Nokia helps make Chengdu region into a smart powerhouseGo and Steel are available to purchase today in the U.S., U.K., and Europe. Steel HR will be available in the fall in the U.S. and at a similar time in the U.K. and other countries.Alongside the rebranded smartwatches, Nokia has launched a cheaper version of Withings body scale, which measures weight and BMI. It is available for $60. Withings original body scale is now named Body+ and adds full body composition for an extra $40.Nokia will also continue to sell the Body Cardio scale for $180.Withings blood pressure monitor will remain on sale for $100, now named Nokia BPM. A premium version of the monitor will be available for $130.Nokia has revamped the Health Mate app as part of the rebranding, it has five new programs: Better Body, Healthier Heart, Leaderboard, Pregnancy Tracker, and Sleep Smarter. The company has added an eight-week wellness programs as well. Can IoT Bridge The Gaps In Modern Mental Health… David Curry Related Posts
From high-speed car chases to luxury car commercials, camera cars are secretly driving alongside capturing all the action.Cover Image via Camera Car IndustriesCamera cars come in all shapes and sizes. They are classified as self-propelled vehicles engineered for mounting and manning cameras and equipment. They are often painted or wrapped in a matte black finish, so they don’t reflect light while shooting.Their history goes all the way back to the first mass-produced vehicles. In this photo from the 1925 film Ben-Hur: A Tale of the Christ, a camera car prepares to film the chariot race sequence.Image via Iverson Movie RanchBy the 1930s, picture cars (the cars that are on camera) were commonly placed in front of rear-projection screens. That technique of process photography has been adapted and is still used today, but with green screens. Action films of the 1940s and 1950s started using cameras on and inside moving vehicles, and by the 1960s we would see the beginning of the modern camera car.Insert CarImage via Elliot Location EquipmentThe insert car (which is actually almost always a truck or van) is a vehicle with a series of platforms that hold a camera crew and their equipment. It is a camera crew’s fully functioning mobile set.It allows an array of different camera and lighting setups, like plate-shots or crane-shots. The insert car also has an on-board generator used to power any camera equipment or light kits. Typically, the film’s director is sitting inside the cab watching footage, while camera operators stand on the platforms filming.The insert car can be driven in front of, behind, or to the side of a picture car. Most frequently they are used to tow picture cars. They are also used to film establishing shots, often just driving through city streets.Process TrailerImage via Moving PicsThe process trailer is a low rise platform that holds a picture car. The trailer moves along roadways, allowing the camera crew to film a natural-looking car movement. They can also be referred to as an insert trailer or a low loader.These are frequently used if no other vehicles will be visible near the picture car. If other vehicles pass by, the height difference will make it apparent that the picture car is on a trailer.Most insert cars can tow the process trailer with a rear trailer hitch. However, there are some insert cars that can also side-tow the process trailer, allowing filmmakers to have camera in front and beside a picture car simultaneously.Image via Camera CarsTow DollyImage via Camera CarsA tow dolly is a specialty trailer that only holds the front tires of a picture car. (These are the types of trailers you frequently see movers using, like U-Haul.)These are usually used when the camera crew is relying on car-mounted rigs, rather than standing beside the vehicle. They also offer a more natural look when driving through traffic, as there isn’t much of a height difference next to other cars on the road.If pulled by an insert car, the most common setup is a camera on the insert car facing the picture car straight on while an additional camera is mounted to the side of the vehicle.Camera Car – Sport Utility Vehicles (SUV)Image via Pursuit SystemsSUV camera cars have become the most well known among people outside of the industry. These camera cars are flashy, usually a modified Porsche Cayenne or Mercedes-Benz ML55 AMG.These high-end SUVs are not only chosen because of their looks, they can seat five crew members and are built for speed. They also feature a solid braking system, which allows them to keep up with high-speed shots and then stop on a dime. Camera Car – CarsImage via Pursuit SystemsThough the SUV has become the most well-known camera car, there are still plenty of camera “cars” used on set. Camera cars are used for high-speed chases or close-up follow shots of vehicles.The Mini Cooper featured above was specifically designed for the Fast & Furious franchise. It was used to film the races inside of parking garages.Camera Car – CustomImage via House of PropsJust like the world of custom cars, there are plenty of custom camera cars as well. Many companies build original vehicles for specific films. One of the most popular is the Go Mobile.Go Mobile is a flat vehicle that allows a film to use any type of vehicle body. The above feature taxi frame can be replaced, and another body type put it its place.Image via Aint It Cool NewsAnother custom vehicle was the one above, built for Children of Men to capture the incredible long take. The custom camera car actually has two drivers, depending on which direction the vehicle is moving. Camera Car – CartsImage via Telescopic Camera CranesCamera cars are not always the fastest or most powerful vehicles. Often times a production may need a silent vehicle or a low-impact cart. These carts can be either gas or electric.By “low impact” we are referring to a vehicle that will not damage a surface, much like in the above photo. The camera car used on the field will not damage the playing surface, whereas a car or truck could weigh it down and leave tire tracks.Interested in more production posts like these? Let us know in the comments below.
England are 24/1 at stumps with Andrew Strauss and Ian Bell at the crease in reply to India’s first innings total of 288 – a lead of 67 runs, on Day 2 of the 2nd Test at Trent Bridge in Nottingham on Saturday. Ishant Sharma scalped opener Alastair Cook early. Score | PhotosRahul Dravid scored his 34th Test ton, but it was England, who finished on an advantageous position as Stuart Broad’s hat-trick wiped out India opener’s good work.Starting the day with an overnight score of 24/1 in reply to England’s first innings total of 221, India banking on Dravid’s impressive form frustrated the England bowlers, who could find and answer to the Wall’s patient innings.Dravid got the support he required from left-hander Yuvraj Singh, as the two employed the right-left combination effectively.Earlier in the day, Dravid and VVS Laxman got busy eating into a scanty first innings total that England had posted on Day 1.KP got into a verbal with Laxman after the caught behind review against him went in the batsman’s favour.It was advantage Laxman early in the innings when during James Anderson’s over England’s review got turned down. With that they ended up using both their reviews and that to unsuccessfully.Soon Laxman went on to complete his half-century. But his delight was short lived as England paceman scalped him on 54 with an away moving ball that took an edge of his bat to land in wicketkeeper Matt Prior’s gloves when India’s total was 93.Then it was the turn of the Master Blaster, Sachin Tendulkar, to make an appearance in the middle. And Tendulkar, who is still one short of his 100th international ton, started his innings in style, hitting a four off Bresnan on the fifth ball that he faced during the day.advertisementTendulkar and Dravid were at the crease and India were on 117/2 when lunch was taken on the second day.Minutes into the second session Sachin Tendulkar was seen walking back on a scanty 16 on board. And once again it was Stuart Broad who managed to disappoint Sachin’s fans just like he did during the first innings of the Lord’s Test. An away moving ball was edged by Tendulkar and England captain Andrew Strauss made no mistake in the slips cordon. India lost their third wicket on 119.Rahul Dravid, who has been playing the role of the opener with lan in the absence of regular openers Virender Sehwag and Gautam Gambhir, scored his half-century with precision. Happy Birthday James!However, his partner in the middle Suresh Raina didn’t last long and fell to a James Anderson ball, which would have been better left than played as it was wide outside off. He prodded it and there was virtually no foot movement and Eoin Morgan did the rest at gully. India lost their fourth wicket on 139/4.Post that fall Dravid and Yuvraj Singh batted on at easy as the scanty first innings lead by England gradually got wiped out. At tea, India were 215/4, trailing by six runs.An interesting tweet: Even as the world waits for Sachin’s 100th ton, Dravid continues to pile his tonsIn the third session the went ahead and started to pile up runs to the frustration of the opposition bowlers. Soon the two batsmen reached their respective milestones, Yuvraj Singh scored his half-century while Dravid completed his 34th Test ton. Finally, England managed to get a breakthrough when a Broad’s ball took a faint edge off Yuvraj’s bat and landed in the safe hands of keeper Prior. He fell for 62 as India lost their fifth wicket on 267.This is Stuart Broad’s first hat-trick against IndiaSoon India’s innings hit a sudden low as England paceman Stuart Broad scalped skipper MS Dhoni, Harbhajan Singh and Praveen Kumar on consecutive balls. Post those wickets India were down to 273 for 8.Then it was the turn of centurion Rahul Dravid to take a walk. Dravid was looking to push Tim Bresnan, but the ball took an aerial route and Alastair Cook claimed him at third man. Dravid, who stood in the middle for the whole day, fell after an impressive innings of 117 that was decorated with 15 fours.Unfortunately, India lost four wicket on 273. Soon it was curtains for India as the visitors were all out on 288 – a lead of 67 runs with Broad claimed six wickets.
Tigers144914481441-7-8 Brewers151015191515-4+5 White Sox145714371441+4-16 Pirates148314831493+10+10 Athletics149015281551+23+61 Blue Jays150714881480-8-27 Angels151015141511-3+1 Marlins144314491439-10-4 The well-traveled, and perhaps forgotten about, Jackson has given the A’s 60 quality innings this season — not bad for a guy playing on his 13th(!) MLB team. Jackson has done this by getting crafty: reducing the use of his fastball from 35.3 percent last season (47.9 percent for his career) to 16.2 percent this season.Among the changes Fiers has made since joining the A’s is creating more separation in height between his fastball and curveball, as Jeff Sullivan found for FanGraphs. He has a 1.47 ERA in three starts with Oakland.Saving more runsThe makeshift pitching staff is also aided by one of the best infield defenses in the game. That’s an effort led by Chapman.While Chapman is an excellent hitter, he’s the best third base defender in the game according to Defensive Runs Saved — and it’s not close. In fact, his 26 Defensive Runs Saved are the best in the game at any position. The next closest third baseman is Travis Shaw of Milwaukee with nine.Chapman leads an elite Oakland infield defense. According to DRS, the A’s also rank second in DRS at first base and eighth at shortstop in the majors. Moreover, Oakland trails only the Arizona in the difference between expected opponent batting average — based on opponent exit velocity — and actual opponent batting average. The A’s are getting to more ground balls and line drives relative to their infielder rivals. Phillies149015071496-11+6 Padres145514461444-2-11 Giants149415021490-12-4 Rays1495151915190+24 The A’s meteoric riseMajor league teams by change in Elo from the preseason and the All-Star Game, as of Aug. 22 Diamondbacks152315231536+13+13 Rockies150315101519+9+16 Royals145914081407-1-52 Twins151014941493-1-17 Mariners150815221507-15-1 Nationals154615221524+2-22 Rangers149714801492+12-5 Braves147415101519+9+45 Red Sox154915901602+12+53 Indians157615551566+11-10 Treinen also has a slider and cutter that baffle opponents. Cardinals152215081540+32+18 Mets149114641484+20-7 Dodgers156815601553-7-15 Cubs155815681543-25-15 TeamPreseasonAll-Star GameCurrentAll-Star GamePreseason EloChange from … Yankees156515891571-18+6 So how did the A’s get here? This isn’t another “Moneyball” story. The once-undervalued metric of on-base percentage is no longer baseball’s best-kept secret — and it’s not even an Oakland staple. The A’s have instead pursued different paths to become one of the better teams in the major leagues despite opening the season with the game’s lowest payroll.Keeping it in the airBecause fly balls and line drives are so much more valuable than ground balls, more and more individual players are trying to launch balls into the air. But the A’s have acquired, and ostensibly tried to develop, the skill at a teamwide level since 2013. As MLB.com’s Mike Petriello found, the A’s have posted five of the eight lowest ground-ball seasons since 2004, including this season’s mark so far. Their average launch angle of 14.9 degrees leads baseball.3The MLB average is 11.7 degrees.While they have acquired fly-ball hitters like Jed Lowrie, Matt Joyce and Khris Davis, they have also developed anti-grounder sluggers in Matt Olson (2012 first-round pick) and Matt Chapman (2014 first-rounder). Lowrie told FiveThirtyEight that he never sat down with an A’s official to talk about his batted-ball profile, but the Stanford University product does use the technology available in the home batting cage for tracking his exit velocity and launch angle to fine-tune his swing.“My guess is they probably identify guys like that to try and acquire [the skill],” Lowrie said of the A’s front office. “It’s part of their calculus.”What on-base percentage was to the Moneyball A’s, fly-ball percentage is to this group of upstarts. That’s made them the league’s fourth-most efficient offense despite a near league-average on-base mark of .322.The A’s are also adapting to their environment. Lowrie notes that Oakland Coliseum is one of the most difficult places in the game to drive the ball, and while the A’s have the lowest ground-ball rate on the road in the majors at 37.8 percent, that rate spikes to 40.9 percent at home, good for eighth-lowest. While Lowrie says teammates Davis, Olson and Chapman can hit the ball “out of Yellowstone,” other A’s alter their approach depending on the ballpark environment. The A’s lead baseball in offensive efficiency on the road with 119 weighted runs created plus (wRC+), a stat that adjusts for park and run environment, with 100 representing league-average performance. But Oakland is only about average at home, with 96 wRC+.Lowrie noted that the A’s set a record for most consecutive road games with a home run this season4They hit at least one homer in 27 straight road games. and that they’ve done much more damage on the road. The Athletics rank 18th in the majors in home runs at home with 67, but they lead the majors in road homers with 106. They are one of the best road teams in baseball at 37-26.“We are playing on a [home] field that is below sea level, with swirling winds that are generally blowing in from right field,” Lowrie said. “We’ve pitched much better at home,” with a 3.32 home ERA vs. 4.30 on the road. “We’ve found different ways to win at home and on the road.”Always be closingThe early 2000s A’s rarely overpaid or valued relievers, believing them to be highly fungible. This Oakland team has the most dominant reliever in the game in Blake Treinen and has further bolstered its strong bullpen with trade acquisitions of Jeurys Familia (2.02 fielding-independent pitching, 19 strikeouts in 15 innings with the A’s) from the Mets and former Twins closer Fernando Rodney.Acquired as a buy-low target with a 5.73 ERA last July in a trade that sent Sean Doolittle and Ryan Madson to Washington, Treinen is second in the majors in relief WAR and owns a 1.00 ERA.While WAR may not be the optimum way to measure a reliever’s value, win probability added (WPA) accounts for the change in win expectancy between every plate appearance. According to WPA, Treinen has been the most valuable pitcher in baseball this season — ranking ahead of aces Max Scherzer, Jacob deGrom and Aaron Nola. His sinker leads the majors in whiffs per swing, and when put in play, it produces 4.6 ground balls for every fly ball. Per FanGraphs pitch values, it’s the fifth-best sinker in the majors. The pitch, with its combination of elite velocity and movement, can make opponents look foolish. The Moneyball A’s didn’t prize defense, fly balls or ace relievers, but this club does. While the formula is different than in the early 2000s, what remains the same is that the A’s are finding value where other clubs are not.Check out our latest MLB predictions. At midseason, the American League seemed decided. The number of tanking teams — some intentional efforts, some unintentional — combined with the AL’s super teams1The top four teams by run differential reside in the AL: the Red Sox, Astros, Yankees and Indians. were conspiring to strip the league of postseason races. The league’s playoff teams seemed all but set by the All-Star Game.But then the Oakland A’s came charging out of the baseball wilderness to give us some late-summer drama.After three consecutive last-place finishes, the Athletics began the year with a 16 percent probability of reaching the postseason and a 6 percent chance of winning the AL West. And just two months ago, they were as many as 11.5 games behind the reigning World Series champion Astros. But after winning 42 of their last 58 games entering Friday, the A’s have cut that deficit to 1.5 games, and they now have an 89 percent chance of advancing to the postseason and a 22 percent chance of winning the AL West.The surge is no fluke. Oakland has the game’s eighth-best run differential, at +94 runs, and has seen the greatest improvement in FiveThirtyEight’s team rating since the start of the season.2As of Aug. 22. Reds146514841474-10+9 Diversifying their pitchesWhile the A’s have a dominant star in the bullpen, the story is different in the rotation. In the early 2000s, the A’s had a trio of front-line starters in Barry Zito, Mark Mulder and Tim Hudson. This year’s A’s team has a rotation populated predominantly by reclamation projects like Trevor Cahill, Brett Anderson, Mike Fiers and Edwin Jackson. Without a legit ace — or even a household name — the A’s rank second to the Red Sox in pitching WPA.Signed to a one-year, $1.5 million contract in the winter, Cahill has become one of the biggest bargains in baseball in part by reducing the use of his fastball and generating more swing and miss with his slider, more than doubling its usage. Cahill has a 3.44 ERA, and his 2.1 WAR according to FanGraphs is the second-best mark of his career.Cahill had once been heavily dependent upon his sinker, but he told FiveThirtyEight that the A’s have given him “weighted pitch” data, which he’s used to diversity his overall pitch mix. For the first time since 2012, he has four above-average pitches, according to FanGraphs linear weights.“If you can throw four different pitches, and they are doing different things in the zone, it’s tough [for batters] to guess,” Cahill said.The A’s also have pitch-tracking Rapsodo technology for use in between appearances, which Cahill uses to monitor his release point and the underlying characteristics of his pitches — like spin rate — between starts.“I go look at my curveball and see if the spin rate is higher,” Cahill said. “I look at where I am releasing it.” Astros157715991585-14+8 Orioles147514221416-6-59
Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 10 Jun 2015 – The door was flung open, the way was cleared and the curious filed in to see what was left of the inside of the famous Junkanoo Club on Goode Street in Grand Turk. The site, built in the early 1970s and where political talks birthed the People’s Democratic Movement and ushered in deeper democracy for the Turks and Caicos has held up well over the years. PDM Leader, Sharlene Robinson said there are serious talks underway to elevate the status of the spot, which is still owned by the McCartneys.Deandrea Hamilton: “Should this be an historical site, should this be a stop on a tour?”Hon. Sharlene Robinson: “Absolutely, absolutely and I am so happy again that the McCartney Family has decided to create a museum and certainly his tomb, his site, the memorial site. That is one thing as party leader I am going to be pushing for because there is no way on my watch, that the young people will not know the history of this man and this movement and not appreciate the lives and the sacrificial service that were laid on the line and the persons who died fighting for a better Turks and Caicos.”Rev Terrance Smith was there in 1975 when the ‘incident’ involving a gun battle standoff with what were called, ‘oppressive’ and ‘victimizing’ members of the Police Force took place.Deandrea Hamilton: Were you scared, what was the mood like on the inside of the building?Terrance Smith: “Never was afraid in my whole life, ain’t never been afraid of nothing; never.”Deandrea Hamilton: Police are shooting at you…Terrance Smith: “Yes but we’re shooting too. Best man win. We were never afraid of the police, the police were afraid of us and that was the problem.”Smith, who remains the party’s chaplain after the weekend convention, was joined by others from that era, including women; we spoke to Rosabelle Adams who with baby in her arms stood watch outside on that fateful night June 6, 1975. “They told JAGS to let him go, JAGS said not until I get what I want for my people. They reported it to the Governor and the Governor came down here and he stood right over there and talked to JAGS. He (Governor Arthur Watson) sent to call JAGS, but JAGS told him (the Goveror) he must come to him; so he came to JAGS and JAGS told him that he wouldn’t let Commissioner Blaze go until he got what he wanted for his people. Now there were other people here in the Junkanoo, but they came of their own free will.”The story goes that JAGS, a cool-headed, determined strategist etched his demands on bits of paper, invited the Governor to come to his turf for negotiations and finally saw the demands of the people acquiesced to – the British warship retreated, an inquiry found the police officers who were from the Eastern Caribbean guilty of firing first in the standoff and by 1976, James Alexander George Smith McCartney was elected the country’s first Chief Minister. A powerful story… as for what was inside the Junkanoo Club when we went in on the 40th anniversary over the weekend; a combination of things old and new, more like a storage space now, pretty much forgotten despite its heavy history, with one token of those times still handing on the wall, a dart board which the likes of Charlie Garland, also a part of the JAGS era believes may have been from the hay day of the club. You can see our One Caribbean TV news report; go to MagneticMediaTV.com Opposition says: Govt slow to restore construction industry; 12-storey debacle no surprise Facebook Twitter Google+LinkedInPinterestWhatsApp People’s Democratic Alliance release song to encourage voter support NHIP controversy sparks rumors of PDM unrest, Premier denies allegations Recommended for you Related Items:charlie garland, goode street, JAGS McCartney, junkanoo club, people’s democratic movement, rev. terrence smith
KUSI Newsroom, SAN DIEGO ( KUSI ) – High winds will buffet the San Diego-area mountains and deserts Thursday evening and Friday, potentially causing driving hazards in some parts of the East County, forecasters advised Thursday.Due to the gusty conditions, the National Weather Service issued a wind advisory, effective through 9 p.m. Friday in the mountains and the deserts.Wind speeds are expected to range from 20 mph to 30 mph with gusts up 50 mph in those areas over the period, the weather service advised.Roadway visibility could be heavily affected by blowing dust and debris due to the winds, meteorologists cautioned. Drivers of large vehicles, such as motor homes and big rigs, were advised to be particularly wary of using desert roads, especially along Interstate 15 across the high desert. Categories: Local San Diego News, Weather FacebookTwitter National Weather Service issues extended wind advisory through Friday night June 20, 2019 Updated: 7:26 PM KUSI Newsroom Posted: June 20, 2019